I have converted to windows 10. Prior to converting (from Windows 7) Directory Opus was running fine and no high CPU usage. Now, post upgrade to Windows 10, when I first start Directory Opus the CPU usage (as seen in task manager) is at the 90% + level for several minutes. It appears to impact everything I run.
From the description, and assuming the high CPU happens when a window opens, this is probably the best place to start:
Crash, exit or high CPU usage when viewing certain directories