Are you sure it's because of the new version? Have you checked going back to 12.17?
If the toolbars/hotkeys haven't been edited or turned off, it's more likely another piece of software has taken over those hotkeys. (They are fairly common ones.)
You can use HotKeyList to see a list of which hotkeys programs have reserved on your system.
It won't tell you which program has done it, unfortunately, but it will confirm that the key has been reserved by something as a system-wide hotkey which overrides individual applications from handling the key when their windows are active.
(If you have floated or turned off the Operations toolbar in Opus, that could also cause something similar to happen with those keys.)
Well, someone must've changed something. I only updated my Windows in the meantime and Aorus Engine + it's dependencies [RGB Fusion, etc.]. But, when I revert to older version of DO, it stops working, in the latest it does. So "something" must've changed