[quote="atazur"]I just upgraded... still has the same problem.
[/quote]
You could have a testwise look in your Appdata dir (type %appdata% in your location field), checking what is in your hotkeys.oxc file, maybe you can find a hint about what´s possibly wrong.
I have the same command also with Ctrl+Shift+Q and also with Win+A.
It's either they are all working outside of opus or none is working.
Not sure if it helps, but I tried now, it didn't work. I put Opus in focus, tried it again, it worked. Now Opus is in the background and the global keys are working.