Control Panel

I just purchased and installed Opus 11 for Win-7 64 bit. How do I use Directory Opus (DO) to substitute DO for Explorer in the Control Panel

Sorry, that's not possible, as the online manual states:

http://www.gpsoft.com.au/help/opus10/default.htm#!Documents/Prefs/Explorer_Replacement.htm

"God mode" might meet your needs. See this thread.