The crash you are seeing may be triggered by something in the directory that Opus is trying to open when it starts, so it may be worth seeing if double-clicking on different folders causes the crash, or if it only happens with particular folders.
If the crash only happens with particular folders then we have a guide on how to narrow down the cause to a particular file and/or plugin or shell extension.
If the crash happens with all folders, it might be worth reinstalling Opus 10.1.0.0 over the top of your existing install. (Don't uninstall as that will erase your configuration.)
If that still doesn't help, see if any crash-dump files have been created at the same date and time as the crashes.
On the other hand, if the crash only happens during startup and never when you run Opus manually then it may be caused by a shell extension (or possibly anti-virus or something else that gets loaded into the Opus process) which is going wrong if some other component is not ready yet after the reboot. e.g. Some shell extensions talk to the network, which may not be fully established yet early after rebooting, and they may not cope with that properly.