I have no idea of the significance of this, but I'll report it in case it's a clue about something. My desktop has been at the menders, and is now at the wreckers, with no replacement yet, so I have kept out of DO12 until today, when I am installing it on my 64-bit HP ProBook Notebook:
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I backed up my notebook DO11.18.0.0 configuration once again.
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I installed DO12.0.4.0 without uninstalling DO11, then rebooted.
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No configuration wizard appeared, but the visible toolbars were presumably the factory-reset toolbars.
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I installed my new Beta Certificate and did a very, very small tour of these toolbars. My various global shortcuts seemed to be working OK.
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I restored my DO11 configuration rather than fiddle about with the toolbars.
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DOpus did not re-launch. The link file did nothing. Clicking on the .exe file in C:\Programs also did nothing.
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Programs and Features still showed DOpus installed, so I uninstalled it there, with no additional file deletions, and rebooted.
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I installed DO12.0.4.0 again. No reboot required.
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This time I was invited to run through the setup configuration steps, but I cancelled out.
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I changed to shared configuration, which I always use (I didn't look at that setting the first time).
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I re-launched DOpus, then restored my previous DO11 configuration once again.
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This time DOpus started up again with my DO11 configuration, and with no problems.
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I installed my new Beta Certificate, and order is restored to the kingdom.