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Eliminating file explorer altogether

When I save files in MS Office applications, the 'save' function pops up with file explorer. Can I set Directory Opus up as the default?

No, there's no way to do that.

Is there a way to direct all 'save' options to show Opus?

No, sorry. There isn't a good way to do that in Windows that doesn't cause lots of problems. Especially not with Office which tends to use completely custom save/open dialogs.