Running DO 12.27 on Windows 11 x64 build 22000.675. I have two 80cm monitors, one with a resolution of 2560x1600, the other a 4k 3840x2160 monitor. The lower res monitor has UI scaling set to 100% and the 4k monitor set to 150%, so that UI text and other elements are approximately the same size on both monitors, and this works fine. The problem I have is that, when the DO image viewer is positioned on the 4k monitor, and I open a 4k image and select View / View Size / Original Size off the menu, it actually shows the image at 150%, though the status bar at the bottom of the window indicates 100%.
If I open the same image in Photoshop on the 4k monitor, and tell Photoshop to scale it at 100%, then it displays correctly at 100%, ignoring the UI scaling setting of the monitor, so it's obviously possible for this to be done.