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Labels not being what you expect them to be:
What do you have under these pages?:
- Preferences / Favorites and Recent / Labels
- Preferences / Favorites and Recent / Label Assignments
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Alt-4 hotkey:
I don't think alt-4 was ever part of the default configuration. If you tell us what alt-4 used to do, we should be able to tell you how to re-create a button or hotkey to do the same thing.
If the issue is you've upgraded from Opus 11 to Opus 12 and now have the default toolbars instead of customized ones, see Your Old Toolbars Are Still There After You Upgrade for how to get them back, if you want them back.