Multiple instances of Directory Opus (with SuRun)

No, and you should not run Opus elevated at all because it breaks interactions between Opus and non-elevated programs.

Opus has its own UAC support, including the optional Admin Mode where, with a single UAC prompt, you can elevate an Opus window so that everything run in it is then elevated without further prompting.

See the FAQ: Why NOT to run Opus as Administrator in Vista / Windows 7.