You can probably keep using both, and either disable the Comodo shell extension system-wide, using ShellExView, or block it just from certain parts of Opus, using the ignore_context_menus setting. (Whether system-wide blocking is needed will depend on exactly how it is going wrong, so you may or may not need that.)
Shell extensions just provide icon overlays and/or ways to launch things via right-click context menus on files. They're rarely needed for the program that they are part of, which will almost always still work with them disabled, as long as there are other ways to access its functionality. The only thing to remember is that updates to the program may re-activate its shell extension, if the system-wide blocking option was used.
Details on blocking shell extensions can be found here: