This is an old thread, but I have been suffering from Directory Opus not responding for a while and have fixed it following advice I found here.
I use Directory Opus Lite (v12.21 x64) on Win10. Symptoms were:
DO locking up, not responding (never while actually in use, but randomly when I came back to it).
Sometimes the Folder Tree panes wouldn’t work but the file panes would still respond.
Right click was always slow (I did not realise that was a symptom until I read this thread!).
Sometimes when not responding DO could be terminated by clicking on the ‘x’ top right. If so DO would not start again until the computer had been restarted. Sometimes it might start partially but the panes would not populate.
Sometimes when not responding DO could be killed from Task Manager. If so DO would not start again until the computer had been restarted.
Occasionally the whole computer would freeze, requiring the power button to be held down to force a power down.
Having read this thread, I downloaded Shellexview, and took the nuclear option of disabling all non-Microsoft shell extensions (100s of them). I have had no problems with DO since. I also have not noticed any differences in any other programs.
Thanks Leo.