dopusrt.exe will stop running (and no longer be run at startup) if you set Preferences / Launching Opus / From the Desktop to Disable.
Does the problem only occur for the folder in your screenshots? If so see the FAQ on Crash, exit or high CPU usage when viewing certain directories.
Failing that, all I can think to suggest is the list of General slowdown or instability investigation steps.
FWIW, Registry cleaners tend to break things more often than fix them.