Only thing I can think of to try is this:
[ul][li]Exit Opus.[/li]
[li]Using Explorer, go to C:\Program Files\GPSoftware\Directory Opus[/li]
[li]Right-click dopus.exe and choose Run as Administrator. This will run it, just this once, with full admin rights.[/li]
[li]Open Preferences in Opus, turn off Explorer replacement, then OK Preferences.[/li]
[li]Opus Preferneces again, turn Explorer replacement back on, then OK again.[/li]
[li]Exit Opus.[/li]
[li]Start Opus again normally (not as admin).[/li][/ul]
If that fixes the Win-E shortcut then there must be a registry value that Opus is failing to write due to UAC. I have run Opus as admin once or twice in the past so this may explain why it works for me.
If it does fix it let us know and I'll make sure the problem is fixed.
Of course, it's possible there isn't a problem here at all and something else is the cause.