I've dropped ActivePython in favor of python.org python + pywin32 (the latest release - 4 days ago).
There are two packages to install instead of one, but, other than that, I have noticed no set-up differences, and you have (lots of) support - like 24/7 channel on IRC with 1500 ppl actually giving answers. All issues reported by me lately are related to pywin32. They may be pywin32 problems (which is expected to be fixed on pywin32 site), DOpus problems (which you may or may not fix), or my problems (as I have had almost nothing to do with ActiveScripting so far, and COM is philosophy on its own).
I do not ride my horse exclusively, as it seems a couple of people is interested.
As I've stated, for a couple of small tasks there is not a lot of difference, and I am not evangelizing around here. For anything bigger, it simply really makes a difference.