Configuration changes happen constantly, just from using the program.
All Opus configuration data is stored in files which can be copied normally, so any backup tool can do the job, from full disk image snapshots through to just copying the files with a simple batch file.
The backup & restore command can also be automated, if you want to use it (but you don't have to, at least not for this kind of backup). And Opus scripts can run commands or file copies when triggered via various events, if you want to do everything from Opus (but then you're only backing up your Opus settings; it might make sense to backup all of your program settings using a broader approach).
So I think everything is already there for automated backups to be done in almost any way you wish.