This is a long shot but try double-clicking the Opus_SetDllDirectory_Disable.reg in the attached zip, then restarting Opus.
Opus_SetDllDirectory.zip (681 Bytes)
Important: After making the registry change, fully exit Opus and then restart it. (Don't just close all the Opus windows. Exit it completely as described in the linked post. If in doubt, reboot after applying the registry file.)
If it doesn't help, do the same with the other .reg file in the zip to go back to normal. (The normal mode is more secure, but causes problems for some shell extensions.)