I'm running Directory Opus 12.26 x64 on Windows 10 Home.
This seems to be a recent issue with this latest version, as I don't recall having this issue before upgrading to 12.26.
What is happening is that I can't drag and drop files (to move/copy) between Lister windows within Directory Opus, nor can I drag from DOpus to an external application (such as to a Thunderbird compose window to attach a file to an email).
Drag and drop seems to be working fine from e.g. Windows File Explorer, but not to/from/within Directory Opus.
That is:
File Explorer -> Thunderbird: OK
DOpus -> Thunderbird: Not working
File Explorer -> DOpus: Not working
DOpus -> File Explorer: Not working
DOpus -> Thunderbird: Not working
DOpus -> DOpus: Not working
I have not changed any of the default events in the File Types settings.
The issue also seems to remain after closing & reopening DOpus, and even after a system reboot.
Keyboard shortcuts (Ctrl-C/Ctrl-X and Ctrl-V) do seem to work between lister windows, so it's just the mouse drag-and-drop.
I've tried several different files, in different directories.
None.
Only Windows Defender, but I don't think it's blocking Opus.
I can, for example, double click on a file in Opus and have it open in its normal default application. It just seems to be drag-and-drop that's broken.
Good point about Defender not blocking other actions; we can rule that out.
Drag & Drop not working can sometimes be caused by a previous drag from or to the program not being completed by one end of the drag & drop. We might be able to catch that happening, or maybe something else that's wrong, if you try a few drag & drops from/to Opus, and then take some process snapshots:
We can look at the snapshots and see what the different threads are doing and if any of them is blocking on our code or someone else's, and hopefully see why.
Unfortunately, they don't show anything definite as the cause. All the threads look fairly normal and are idle, with nothing stuck in the middle of a drag & drop or anything like that.
There are some components from cloud storage software which are in the snapshot and may be worth investigating:
pCloud Drive
Google Drive File Stream
Box Sync
With Box Sync in particular, a January update of that seems to be causing some strange issues for some people, which could also explain the problem you're seeing, as well as the way it only started happening recently. File Stream also looks like it was updated in January, which could be relevant.
You could try uninstalling them, but a quicker (albeit less definite) test could be to use ShellExView 64-bit to disable any shell extension DLLs related to either product (including any mentioning "cbfs" which is a component Box seems to use).