If you haven't already, please try using the latest beta ( Directory Opus 13.11.4 (Beta) ) in case it's something that was fixed recently.
If that still has the problem, we might be able to work out the cause from some process snapshots, made while the error message is still on-screen.
(I would not worry about hardware errors, unless you're seeing random issues with other software as well. This is more likely to be a bug in either Opus or a DLL something has installed on the system which gets loaded during startup.)