I've create a file type format for MP3 files. When I turn that on, the file view refreshes all 2 seconds and I can't find out why.
I have had a folder format defined (on a specific folder) which I have unchecked to not collide somehow with the file type format but that did not help.
Are the files on a QNAP brand NAS (network storage) by any chance? Sounds a lot like this thread.
If not, chances are something keeps modifying the files in that folder, or keeps reporting to the OS (and thus Opus) that the files are being modified even if they aren't.