When I go to Help » Help or hit the F1 key, nothing happens — no error message, no new process created (as far as I can tell), nothing.
I would've checked to see if the help file itself still exists, but I'm not sure where to look.
My best guess would be that a missing help file would still result in some kind of error dialog, and since a reinstall restores the ability to call the Windows Help file for Directory Opus, I suspect it's a registry entry that goes missing.