I use Opus on a desktop PC and a laptop and I like to use the same configuration on both systems. However, my userID is different on each machine so a "My Documents" layout created on the laptop referring to C:\Users\LaptopID\Documents does not work "as is" on the desktop where it needs to refer to C:\Users\DesktopID\Documents. Likewise..
C:\Users\LaptopID\Downloads needs to refer to C:\Users\DesktopID\Downloads,
C:\Users\LaptopID\My Pictures needs to refer to C:\Users\DesktopID\My Pictures,
The way around this is to manually edit the relevant "MyLayout" file and replace occurences of C:\Users\LaptopID with the built-in Opus alias /profile, so that C:\Users\LaptopID\Documents becomes /profile\Documents and C:\Users\LaptopID\Downloads becomes /profile\Downloads. Since /profile refers to the current userID it works properly on both systems.
An Opus layout named MyLayout is defined in a file called MyLayout.oll. You can easily find the folder that contains all of your opus layouts (OLL files) by typing /dopus\layouts in a lister window.
N.B. Before you make any changes to a layout, I strongly recommend that you make a copy of the original OLL file and/or backup your configuration.