Ever since DOpus 10 has come out (as far as I have noticed) , the imageshack upload has failed with an error even tho I can upload manually without a problem.
64 bit
Works here, FWIW:
img199.imageshack.us/img199/4584/wc856dopus.png
If it has never worked you may need to configure Opus to use a proxy or something. Or you might have firewall software blocking dopus.exe from sending data to imageshack.
Turned off the firewall ... same results.
Is there a way to get more specifications what the error is ?
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Confirming leo's. Never had any problems here either. winxp 32-bit
good luck with the trouble shooting 
I have a screenshot utility that uploads to Imageshack without a problem
That doesn't discount proxy settings or a firewall blocking (some versions of) dopus.exe.
Not that those are the only things that could be going wrong, but have you looked into either of them?
Yes, I said I tried withmy firewall off .. I don't have any proxy settings on, if that is what u mean.