I know you're working on a better responsive for different dpi, but I don't know what has already been done and what might be a bug.
I have a 21:9 monitor and set Windows-scale 125%. When accessing a PC via RDP using a smaller res at 100% scale, closing RDP and login local to the PC, DO's fonts are too large (exiting DO and restart doesn't help, a sys-restart is necessary).
On the other side in RDP on lower res/scale fonts are same size like the original local scale.