I have been having this issue for many months now. It happened on the previous version of Directory Opus, and I recently upgraded to Version 12 hoping this might fix the problem, but it hasn't. It's a little hard to describe, so I have included a screenshot. Basically the problem is this - I go to lunch (for 30-45 minutes every day), and when I come back the interface of Directory Opus has gone strange - for example, the area that holds the back, forward, up and favourites buttons has turned black, and all buttons have been replaced by stars. The toolbar buttons develop thick black lines and there are large grey areas in the directory listing area (like I said, screenshot shows it better than I can describe it). While Directory Opus continues to work in this visually degraded state it is really slow and takes ages to redraw each screen.
If I close Directory Opus down and reopen it, everything is back to normal again.
I am running Windows 7 SP1 x64 with 16Gb of RAM and an NVidia Quadro 2000 graphics card. None of the other programs that I leave running over my lunch break experience any problems, just Directory Opus. And it ALWAYS does this, EVERY lunchtime (or every time I take a break of more than a few minutes)