Excluding folders has to be done using a filter (Advanced mode). This explains how it works:
You could save what you want as a named filter, with the extra fields/conditions you want to modify each time included as well, so you can just type the parts that change into it.
A command like this will load your filter into the Find panel and set the search paths:
Find NOAUTORUN FILTER NAME="Your Filter Name" IN "C:\abc" "D:\xyz"
(If you don't want to type anything or change what you're searching for each time, and want to repeat the same search fully automated, without even opening the Find panel, remove the NOAUTORUN
argument and it'll do that.)
You can create and save the filter itself within the Find panel's Advanced tab, or via Preferences / File Operations / Filters. (Using the Find panel is easier, since you can try it out right there.)
(Making it easier to exclude paths without using filters might happen in the future, FWIW.)