You can write anything to multiple types of metadata simultaneously with a script. But you cannot write to both descript.ion and to the NTFS (ADS) extended comments as far as I know - because in both cases the field 'description' (or 'userdesc') is used, and this field will redirect your comment either to ADS or to descript.ion. This is an implementation choice made by the Opus guys.
See also File comments/ descriptions and "descript.ion" in Opus (it remains to be seen if anyone will pick this up at Opus - it's their decision whether they think the change is worth it or not).