If you're just copying a file, the content of it should not matter, unless antivirus is scanning it. I would look in that direction if it only happens with zip files and not other files of a similar size.
But if it's also affecting other things, like Macrium backups, then there's probably a network problem, and the server (or client) is dropping off the network when under load.
Problem here is that hardware things were checked and tested with various setups, and I came to point where certain odd files simply act differently compared to thousands of similar others.
So I though maybe someone could give a hint how to gather deeper logs in DO for example.
Because in Macrium logs are pretty plain without any details.