My folder structures are pretty complex and deep. Many of them seem similar (especially where I have several versions of code, each in its own folder).
My suggestion is to enhance DOpus so that when I hover over a file or a folder in the Folder Tree pane, it would display a pop-up balloon that would show me the full path (including drive) of the file/folder.
This invaluable 'tip' would allow me, at a glance, to tell where in the tree I am positioned.
For the file display, you can edit info tips under Settings > File Types.
The All Files and All Folders are the main types you might want to edit, along with the ones under File Type Groups (ignoring the Archives group, which doesn't have an Info Tip defined by default, and thus gets the All Files one).
You can add any fields you wish to the Info Tips there, including the General > Full Path field.
