The only problem I've noticed with DO and Windows 11 is the OneDrive commands are missing from the context menu. In Windows 10, if you right-click on a OneDrive folder/file, you would see a OneDrive menu that let you do things like "Free up disk space" or "Make available offline".
If I'm working with OneDrive files, I have to go back to the Windows 11 File Explorer.
Otherwise, I've had no other issues with DirectoryOpus.