A couple of quick things to check:
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Does it still happen without the Owner and/or Status columns?
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If you look in Task Manager, is dopus.exe or anything else (e.g. antivirus) using a lot of CPU when this starts happening?
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What type of drive is this happening on? e.g. Local drive, Windows network drive, or non-Windows network drive.
If you can send us some process snapshots so we can see what's happening while the program is unresponsive, we may be able to see what's going wrong from those: