No, there was no Hardware failure.. I had 2 SSDs in RAID 0 for a long time, and recently was told that it makes them slower. I noticed that they were not running up to spec. And it was my C: Windows Drive. So I used Acronis True Image 2016 to make a backup image of my D: drive, and then used the 'Clone Disk' utility to move C: Windows to my D: M.2 Drive. That booted up fine. I didn't test DOpus at that time. I just made sure it booted ok and ran ok, so I rebooted a few times. At boot the system had changed my D: M.2 Windows drive to letter C. And all was good. So, I removed my 2 SSDs from the RAID 0 and made them separate drives. Then I Cloned Windows from that C: (D:) drive back to one of the SSDs because that's where I wanted Windows. Now that drive was C: and it boots up fine. But then I went to use DOpus and got an Error that my license was invalid or something. I got that error maybe 2-3 times. I think I rebooted a few times and tried it again and now it says this error that I first posted about..
Windows or the BIOs has always changed the Windows Drive to C: every time. Which I like..
I ran the Error Check tool in the C: Properties page and it found no errors. And I Defragged it but it didn't need it. It ran in about 4 seconds.